Thermo Fisher Scientific Phospho-LATS1 (Ser909) Polyclonal Antibody
Phospho-LATS1 (Ser909)를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. Human과 Mouse 시료 반응. PBS/glycerol buffer에 보관되며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS1 (Accession O95835), corresponding to amino acid residues around phosphorylated Ser909 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816871 |
Product Specific Information
This antibody detects endogenous levels of LATS1 only when phosphorylated at Ser909.
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner. The N-terminal region binds CDC2 to form a complex with reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation via intramolecular binding. LATS1 acts as a tumor suppressor and plays an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors, and sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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