Thermo Fisher Scientific Phospho-LATS1 (Thr1079) Polyclonal Antibody
LATS1 단백질의 Thr1079 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL, -20°C 보관. 연구용으로만 사용.
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- PA5105442
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS1 (Accession O95835), corresponding to amino acid residues around phosphorylated Thr1079. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816870 |
Product Specific Information
Antibody detects endogenous levels of LATS1 only when phosphorylated at Thr1079.
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with the cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through intramolecular binding. LATS1 acts as a tumor suppressor and plays an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogenic treatments.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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