Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI14C5), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express PD-1 (PDCD-1), which mediates inhibitory signals via ligands PDL-1 and PDL-2.
Binding of PD-1 to these ligands suppresses immune activation in the absence of danger signals (e.g., LPS). PD-1 knockout mice exhibit hyperactivated immune systems and autoimmune symptoms.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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