Thermo Fisher Scientific TP53BP1 Monoclonal Antibody (OTI2G3), TrueMAB
TP53BP1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(P) 등에 적합. Human 시료 반응성, 무보존제 PBS 버퍼에 동결건조 형태로 제공. DNA 손상 반응 및 종양 억제 연구용으로 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G3 |
| Immunogen | Human recombinant protein fragment (aa 1–300 of TP53BP1) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a substrate of ATM kinase. Upon DNA damage, 53BP1 becomes phosphorylated and localizes to double-strand break sites. It is involved in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and contributes to genomic stability through DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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