Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI16D4), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

T lymphocytes initiate cell-mediated immune responses upon stimulation by peptides bound to MHC molecules on antigen-presenting cells (APCs). Activated T cells express inhibitory receptors such as PD-1 (also known as PDCD-1), which mediate negative regulatory signals through interaction with its ligands PDL-1 and PDL-2.
Binding of PD-1 to these ligands suppresses immune activation in the absence of danger signals. PD1-deficient mice exhibit hyperactivated immune systems and autoimmune phenotypes. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.