Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1.0 µg/mL

View 1 publication 1 publication

Immunohistochemistry (IHC)

5 µg/mL

-

Immunocytochemistry (ICC/IF)

10 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL-22 Receptor alpha,uniProtId:Q8N6P7-1,ncbiNodeId:9606,antigenRange:1,antigenLength:574,antigenImageFileName:PA5-19987_IL-22_Receptor_alpha_Q8N6P7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-19987_IL-22_Receptor_alpha_Q8N6P7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11154081

Product Specific Information

In Western blot applications, this antibody detects a band at ~62kDa. A suggested positive control is HepG2 cell lysate.

PA5-19987 can be used with blocking peptide PEP-0111.

Target Information

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.