Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody
IL-22 수용체 알파를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human 및 Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 2–8°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154081 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 62 kDa.
- Suggested positive control: HepG2 cell lysate.
- PA5-19987 can be used with blocking peptide PEP-0111.
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling through the JAK-STAT pathway.
IL22R is expressed in normal liver and kidney tissues and in cell lines such as HepG2 and TK-10.
A soluble form of IL-22 receptor, termed IL-22 binding protein (IL-22BP) or IL-22 receptor-alpha 2 (IL-22RA2), was recently identified.
IL-22BP prevents binding of IL-22 to the functional IL-22R complex and neutralizes IL-22 activity.
LPS induces IL-22 expression, indicating its role in inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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