Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody
IL-22 수용체 알파를 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화됨. 인간 및 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 버퍼에 0.02% sodium azide 포함, 2–8°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA519986
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 560–574 of human IL-22 receptor precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157663 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 62 kDa.
- Suggested positive control: HepG2 cell lysate.
- PA5-19986 can be used with blocking peptide PEP-0110.
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a member of the class II cytokine receptor family.
IL-22R forms a complex with the IL-10 receptor beta chain and mediates IL-22 signaling via the JAK-STAT pathway.
IL22R is expressed in normal liver and kidney and in cell lines such as HepG2 and TK-10.
A soluble form of the IL-22 receptor, also termed IL-22 binding protein (IL-22BP, IL-22RA2), prevents IL-22 from binding to the functional IL-22R complex and neutralizes its activity.
LPS induces IL-22 expression, indicating its role in inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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