Thermo Fisher Scientific GP130 Monoclonal Antibody (28126)
인간 gp130 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry 및 Neutralization 실험에 적합합니다. 높은 특이성과 낮은 엔도톡신 수준을 가지며, 단백질 A/G로 정제되었습니다. 동결건조 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 2.5 µg per million cells |
| Neutralization (Neu) | 0.04–0.2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 28126 |
| Immunogen | Sf21-derived recombinant human gp130 extracellular domain |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608855 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant human IL-2 R, IL-4 R, or IL-6 R is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The protein encoded by this gene is a signal transducer shared by multiple cytokines, including IL-6, CNTF, LIF, and OSM. It functions as part of the cytokine receptor complex, with activation dependent on cytokine binding. The viral IL-6 (vIL6) from Kaposi sarcoma-associated herpesvirus can directly activate this protein, bypassing IL6R. Knockout studies in mice indicate a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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