Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), FITC

Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 20 µL / 1×10⁶ cells
Publications: View 2 publications

Product Specifications

Available Formats

• Unconjugated
• APC
• Biotin
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, zeta), essential for surface expression and signaling. TCR activation leads to T cell differentiation, proliferation, and cytokine production. Most human T cells express TCR alpha/beta heterodimers, while gamma/delta T cells are mainly localized in epithelial tissues.

TCR recognition of self-peptides is linked to autoimmune diseases, and mutant self-peptides are associated with tumors. Superantigen engagement of TCRs can cause toxic shock syndrome. Autoantibodies to V beta segments of TCRs are found in rheumatoid arthritis and lupus patients, potentially modulating inflammatory responses.

T Cell and TCR Diversity

• Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive).
• A small subset lacks both (double negative), increased in certain autoimmune or immunodeficiency disorders.
• Gamma-delta T cells reside primarily in epithelial tissues, showing less diversity and distinct antigen recognition, with known antitumor and immunoregulatory roles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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