Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), PE
인간 TCR α/β를 인식하는 단클론 항체(IP26)로, PE 형광표지되어 유세포분석(Flow Cytometry)에 적합합니다. PBS 완충액에 보관하며, 4°C 암소 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IP26 |
| Immunogen | Not available |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153184 |
Additional Formats
- Unconjugated (MA1-10451)
- APC (MA1-10452)
- Biotin (MA1-10453)
- FITC (MA1-10454)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.
Target Information
The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, and zeta). These are essential for surface expression and signal transduction. Activation through the TCR leads to T cell differentiation, proliferation, and cytokine production.
Most T cells in blood and lymphoid organs express TCR alpha/beta heterodimers, while TCR gamma/delta T cells are mainly localized in epithelial tissues and infection sites.
Proper assembly of TCR-CD3 complex in the endoplasmic reticulum is required for surface expression; lack of any subunit prevents expression.
TCRs discriminate self from foreign peptides presented by MHC class II molecules, a process crucial for adaptive immunity. Dysregulation or recognition of self-peptides is linked to autoimmune diseases and tumors.
Superantigen engagement of TCRs can cause toxic shock syndrome. Autoantibodies against TCR V beta segments have been identified in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, potentially modulating inflammatory responses.
Most human T cells express TCR alpha-beta with CD4 or CD8 (single positive), while a smaller subset lacks both markers (double negative). Increased alpha-beta double-negative T cells are observed in certain autoimmune and immunodeficiency disorders. Gamma-delta T cells, found mainly in epithelial tissues, exhibit limited diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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