Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26)

Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26)

Applications

• Flow Cytometry (Flow)

Tested Dilution: 2–4 µg/mL
Publications: View 3 publications

Product Specifications

Available Formats

• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression.
T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines.
Both the CD3 and TCR zeta subunits are proposed to be responsible for intracellular signal transduction events.

Most T cells present in the blood, lymph, and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and sites of infection.
The subunits of TCR heterodimers are covalently bonded and associate with CD3 subunits in the endoplasmic reticulum to form a functional TCR-CD3 complex.
Lack of expression of any chain is sufficient to stop cell surface expression.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by MHC class II molecules is essential for an effective adaptive immune response.
TCR recognition of self-peptides has been linked to autoimmune disease, and mutant self-peptides have been associated with tumors.
Engagement of TCRs by bacterial superantigens has been responsible for toxic shock syndrome.
Autoantibodies to V beta segments of TCRs have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), blocking TH1-mediated inflammatory reactions.

T Cell and TCR Diversity:
Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive, SP).
A small number of T cells lack both CD4 and CD8 (double negative, DN).
Increased percentages of alpha-beta DN T cells have been identified in autoimmune and immunodeficiency disorders.
Gamma-delta T cells are primarily found within the epithelium and show less TCR diversity, recognizing antigens differently than alpha-beta T cells.
Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.