Thermo Fisher Scientific PON3 Polyclonal Antibody
Thermo Fisher Scientific의 PON3 Polyclonal Antibody는 인간 및 생쥐 시료에서 PON3 단백질을 검출할 수 있는 고품질 항체입니다. Western blot, IHC, ICC/IF에 최적화되어 있으며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정적인 PBS/glycerol buffer로 보관이 용이합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PON3 (Accession Q15166), corresponding to amino acid residues L258–N308 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852369 |
Product Specific Information
Antibody detects endogenous levels of total PON3.
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL. It prevents oxidation of LDL, thereby reducing formation of atherogenic oxidised-LDL. Human PON1 polymorphisms are correlated with coronary artery disease. PON1 activity is lower in individuals with atherosclerosis-related conditions such as diabetes, familial hypercholesterolemia, and renal disease.
PON2 is an intracellular protein that protects cells against oxidative damage. PON3 is similar to PON1 in activity but differs in substrate specificity. Both PON1 and PON3 are implicated in lowering the risk of coronary artery disease and atherosclerosis. Human PON3 shares conserved cysteine residues found in PON1, suggesting their importance in in vivo activity. PON1-based catalytic scavengers may provide a safe and effective method for organophosphate detoxification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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