Thermo Fisher Scientific ING4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ING4.

Target Information

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors.
All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure.

ING proteins form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including:

• Growth arrest
• DNA repair
• Gene transcription
• Apoptosis
• Senescence

ING4 plays a role in brain tumor pathogenesis and regulates tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, correlating with progression from lower to higher grades of tumors.
ING4 physically interacts with the p65 (RelA) subunit of NF-κB and represses transcription of NF-κB responsive genes.
Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10–20% of human breast cancer cell lines and tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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