Thermo Fisher Scientific MSR1 Monoclonal Antibody (UMAB246), UltraMAB
인간 MSR1 단백질(aa 197-451)을 인식하는 UMAB246 클론의 Mouse IgG1 단일클론 항체. IHC, ChIP, Peptide Array 등 다양한 응용 가능. 동결건조 형태로 제공되며, PBS/trehalose buffer에 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:600
ChIP assay (ChIP)
- Tested Dilution: Assay-Dependent
Peptide Array (Array)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB246 |
| Immunogen | Human recombinant protein fragment (aa 197–451 of human MSR1) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, including three isoforms (types 1, 2, and 3) produced via alternative splicing.
These macrophage-specific trimeric membrane glycoproteins are involved in physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
- Isoform 3, trapped in the endoplasmic reticulum, lacks endocytic function and can inhibit types 1 and 2 (dominant negative effect).
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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