Thermo Fisher Scientific MSR1 Monoclonal Antibody (UMAB246), UltraMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:600

ChIP assay (ChIP)

• Tested Dilution: Assay-Dependent

Peptide Array (Array)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, including three isoforms (types 1, 2, and 3) produced via alternative splicing.
These macrophage-specific trimeric membrane glycoproteins are involved in physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.

• Isoforms 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
• Isoform 3, trapped in the endoplasmic reticulum, lacks endocytic function and can inhibit types 1 and 2 (dominant negative effect).
  Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.