Thermo Fisher Scientific MSR1 Monoclonal Antibody (UMAB247), UltraMAB
인간 MSR1 단백질(aa 197-451)을 항원으로 제작된 마우스 모노클론 항체. IHC(P) 및 ChIP 분석에 사용 가능. 비결합형 액상 포맷, 친화 크로마토그래피 정제. -20°C 보관, 동결/해동 반복 피해야 함.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1200
ChIP assay (ChIP)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB247 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 197–451 of human MSR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CD204 gene encodes class A macrophage scavenger receptors, including three isoforms (types 1, 2, and 3) generated by alternative splicing. These macrophage-specific trimeric membrane glycoproteins are involved in various physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Type 1 and 2 isoforms: Functional receptors mediating endocytosis of modified LDLs.
- Type 3 isoform: Does not internalize modified LDL due to altered intracellular processing and is retained in the endoplasmic reticulum.
- Type 3 can inhibit types 1 and 2 when co-expressed, suggesting a regulatory mechanism for scavenger receptor activity.
Diseases associated with MSR1 include Barrett’s Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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