Thermo Fisher Scientific MSR1 Monoclonal Antibody (UMAB247), UltraMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1200

ChIP Assay (ChIP)

• Tested Dilution: Assay-Dependent

Peptide Array (Array)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, including three isoforms (types 1, 2, and 3) generated by alternative splicing. These trimeric integral membrane glycoproteins are macrophage-specific and play roles in atherosclerosis, Alzheimer’s disease, and host defense.

• Isoforms 1 and 2 mediate endocytosis of modified LDLs.
• Isoform 3 does not internalize modified LDL due to altered intracellular processing and retention in the endoplasmic reticulum.
• Isoform 3 can inhibit isoforms 1 and 2, exerting a dominant negative effect that regulates scavenger receptor activity.

Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.