Thermo Fisher Scientific MSR1 Monoclonal Antibody (UMAB247), UltraMAB
MSR1 단백질을 표적으로 하는 UMAB247 마우스 단클론 항체로, IHC, ChIP, Peptide Array 등에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공되어 안정적 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1200
ChIP Assay (ChIP)
- Tested Dilution: Assay-Dependent
Peptide Array (Array)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB247 |
| Immunogen | Human recombinant protein fragment (aa 197–451 of human MSR1, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, including three isoforms (types 1, 2, and 3) generated by alternative splicing. These trimeric integral membrane glycoproteins are macrophage-specific and play roles in atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms 1 and 2 mediate endocytosis of modified LDLs.
- Isoform 3 does not internalize modified LDL due to altered intracellular processing and retention in the endoplasmic reticulum.
- Isoform 3 can inhibit isoforms 1 and 2, exerting a dominant negative effect that regulates scavenger receptor activity.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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