Thermo Fisher Scientific AGR2 Monoclonal Antibody (UMAB245), UltraMAB
AGR2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, 인체 반응성 확인. IHC(P)에서 1:500 희석으로 사용 가능. 동결건조 형태로 제공되며 PBS 기반 버퍼 포함. 암 연구 및 AGR2 관련 단백질 표적 실험에 적합.
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Thermo Fisher Scientific AGR2 Monoclonal Antibody (UMAB245), UltraMAB
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB245 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 21–175 of human AGR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. These secreted cytoplasmic proteins are involved in metastasis induction and p53 tumor suppressor inhibition.
They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumors.
AGR2 is ubiquitously expressed and upregulated in prostate, breast, lung, renal, and endometrial carcinomas.
AGR2 expression correlates positively with estrogen receptor (ER) and negatively with epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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