Thermo Fisher Scientific PDCD4 Polyclonal Antibody
PDCD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, ICC/IF, ELISA에 사용 가능하며 인간, 마우스, 랫트 시료에 반응합니다. 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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- PA5120813
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–260 of human PDCD4 (NP_055271.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914385 |
Product Specific Information
- Positive test controls: HeLa, MCF7
- Subcellular localization: Cytoplasm, Nucleus
Immunogen sequence:
MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL ALDTPRAPQL
Target Information
Apoptosis, or programmed cell death, is essential for development, tissue turnover, and tumor suppression. PDCD4 encodes a tumor suppressor protein whose expression is lost in several carcinomas (breast, colon, lung, prostate). It inhibits the helicase activity of eIF4A and the transactivation mediated by AP-1. PDCD4 activity is regulated by Akt-mediated phosphorylation. Two isoforms of PDCD4 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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