Thermo Fisher Scientific TCOF1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 659-958 of human TCOF1 (NP_001008657.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TCOF1,uniProtId:Q13428-1,ncbiNodeId:9606,antigenRange:659-958,antigenLength:1488,antigenImageFileName:PA5-120816_TCOF1_Q13428-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120816_TCOF1_Q13428-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.91 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914388

Product Specific Information

Positive test controls include: BT-474, 293T. The target is usually found in the following locations: Nucleus, nucleolus.

Immunogen sequence: VRVGTQAPRK AGTATSPAGS SPAVAGGTQR PAEDSSSSEE SDSEEEKTGL AVTVGQAKSV GKGLQVKAAS VPVKGSLGQG TAPVLPGKTG PTVTQVKAEK QEDSESSEEE SDSEEAAASP AQVKTSVKKT QAKANPAAAR APSAKGTISA PGKVVTAAAQ AKQRSPSKVK PPVRNPQNST VLARGPASVP SVGKAVATAA QAQTGPEEDS GSSEEESDSE EEAETLAQVK PSGKTHQIRA ALAPAKESPR KGAAPTPPGK TGPSAAQAGK QDDSGSSSEE SDSDGEAPAA VTSAQDQESS

Target Information

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.