Thermo Fisher Scientific CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Alexa Fluor 488, eBioscience
마우스 SIGNR1(CD209b)을 인식하는 단클론 항체로, Alexa Fluor 488 형광 표지. Flow Cytometry에 최적화되어 있으며, 499/520 nm 파장에서 발광. 고순도 Affinity Chromatography 정제 및 안정적 PBS buffer 저장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (IHC)
- Not tested
- View 1 publication
Flow Cytometry (Flow)
- Tested dilution: 1.0 µg/test
- View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio22D1 (22D1) |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802324 |
Additional Formats
Product Specific Information
The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b), a type II transmembrane C-type lectin identified as a mouse homologue of human DC-SIGN. It is highly expressed in splenic marginal zone macrophages and lymph node medullary macrophages, where it mediates uptake of dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. SIGNR1 associates with TLR4/MD2, suggesting a role in LPS recognition, and binds complement component C1q to form a non-conventional C3 convertase. SIGNR1-deficient mice show defects in C3 catabolism. The eBio22D1 antibody does not cross-react with SIGNR2, SIGNR3, or SIGNR4.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Validated on mouse splenocytes at ≤1.0 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
Target Information
SIGNR1 is a type II transmembrane C-type lectin expressed in splenic marginal zone and lymph node medullary macrophages. It mediates uptake of dextran polysaccharides and interacts with TLR4/MD2 and complement components C1q and C3, playing a role in immune recognition and complement activation.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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