Thermo Fisher Scientific alpha-ENaC Monoclonal Antibody (2G4), FITC
Thermo Fisher Scientific의 alpha-ENaC Monoclonal Antibody (2G4), FITC는 Mouse 및 Rat 시료에서 ENaC α-단백질을 검출하는 데 적합한 단일클론 항체입니다. FITC 형광 표지로 시각화가 용이하며, Western blot 및 면역조직화학(IHC)에 사용 가능합니다. 단백질 G 정제, 4°C 어두운 곳 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:150 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G4 |
| Immunogen | Synthetic peptide from the N-terminal of Rat ENaC alpha (aa. 46–68) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931804 |
Additional Formats
- APC (Cat. No. MA5-45349)
- PerCP (Cat. No. MA5-45351)
- Custom conjugation available upon request
Product Specific Information
A 1:1,000 dilution of MA5-45350 was sufficient for detection of ENaC alpha in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 85 kDa.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural features, including two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with conserved cysteine residues.
ENaC has three homologous isoforms (α, β, γ) and plays a critical role in sodium and fluid balance in the kidney, lung, and colon. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, contributing to blood pressure regulation.
Mutations in ENaC subunits can cause disorders such as Liddle’s syndrome (gain-of-function in β or γ subunits) and pseudohypoaldosteronism type 1 (loss-of-function in α or β subunits).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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