Thermo Fisher Scientific alpha-ENaC Monoclonal Antibody (2G4), FITC

Applications and Tested Dilution

Product Specifications

Additional Formats

• APC (Cat. No. MA5-45349)
• PerCP (Cat. No. MA5-45351)
• Custom conjugation available upon request

Product Specific Information

A 1:1,000 dilution of MA5-45350 was sufficient for detection of ENaC alpha in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 85 kDa.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural features, including two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with conserved cysteine residues.
ENaC has three homologous isoforms (α, β, γ) and plays a critical role in sodium and fluid balance in the kidney, lung, and colon. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, contributing to blood pressure regulation.
Mutations in ENaC subunits can cause disorders such as Liddle’s syndrome (gain-of-function in β or γ subunits) and pseudohypoaldosteronism type 1 (loss-of-function in α or β subunits).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지