Thermo Fisher Scientific SCNN1B Monoclonal Antibody (7B8), APC

Applications and Tested Dilution

Product Specifications

Product Specific Information

A 1:1,000 dilution of MA5-45352 was sufficient for detection of ENaC beta in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 87 kDa.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception. Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease due to unresponsiveness to mineralocorticoids, and Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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