Thermo Fisher Scientific SCNN1B Monoclonal Antibody (7B8), FITC
SCNN1B 단백질을 인식하는 Mouse 모노클로날 항체로 FITC 형광 표지된 제품입니다. Western blot과 IHC에 사용 가능하며, ENaC beta 단백질 검출에 최적화되어 있습니다. 단백질 G 정제, 액상 형태로 4°C 암소 보관합니다.
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Thermo Fisher Scientific SCNN1B Monoclonal Antibody (7B8), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7B8 |
| Immunogen | Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638) |
| Conjugate | FITC |
| Excitation/Emission Max | 498/517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931807 |
Additional Formats
- APC (MA5-45352)
- PerCP (MA5-45354)
- Request custom conjugation
Product Specific Information
A 1:1,000 dilution of MA5-45353 was sufficient for detection of ENaC beta in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 87 kDa.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
Forms heterotetramer of two alpha, one beta, and one gamma subunit (delta subunit can replace alpha). Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2. Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) and Liddle syndrome, both related to sodium channel dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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