Thermo Fisher Scientific ALK Monoclonal Antibody (OTI5D1), TrueMAB
인간 ALK 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. 액상 형태이며 PBS/BSA/glycerol 버퍼에 보관됩니다. 뇌 발달 관련 연구 및 종양 유래 ALK 변이 분석에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D1 |
| Immunogen | Full length human recombinant protein of human ALK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene consisting of ALK and nucleophosmin (NPM). The NPM-ALK fusion product is oncogenic. ALK is a novel receptor protein-tyrosine kinase with a transmembrane and extracellular domain, which are absent in the NPM-ALK product. ALK shows high sequence similarity to LTK and plays an important role in brain development, affecting specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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