Thermo Fisher Scientific HES6 Monoclonal Antibody (OTI1D6), TrueMAB
HES6 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화됨. Human 시료 반응성. 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D6 |
| Immunogen | Full length human recombinant protein of human HES6 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The HES family members form a complex with TLE, the mammalian homologue of Groucho, mediated by the carboxy terminal WRPW motif of HES proteins. The HES/TLE complex binds DNA directly rather than interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) rather than the E box (CANNTG). HES2 binds both N and E box sites, while HES6 does not bind DNA but inhibits HES1 activity, promoting transcription.
HES1 and HES2 are expressed in various adult and embryonic tissues; HES3 is expressed exclusively in cerebellar Purkinje cells; HES5 is found solely in the nervous system. HES6 is produced in the brain and in the limb buds of developing embryos.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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