Thermo Fisher Scientific HES6 Monoclonal Antibody (OTI1H2), TrueMAB
인간 HES6 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 1:2000 희석 비율로 사용 가능. E.coli에서 생산된 full-length recombinant HES6 단백질을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 저장. 연구용으로만 사용.
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Applications
Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H2 |
| Immunogen | Full length human recombinant protein of human HES6 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The HES family members form a complex with TLE, the mammalian homologue of Groucho, mediated by the carboxy terminal WRPW motif of the HES proteins.
The HES/TLE complex binds directly to DNA rather than interfering with activator proteins.
Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) instead of the E box (CANNTG).
HES2 binds to both N and E box sites, while HES6 does not bind DNA but inhibits HES1 activity, promoting transcription.
HES1 and HES2 are expressed in various adult and embryonic tissues.
HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system.
HES6 is produced in brain and limb buds of developing embryos.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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