Thermo Fisher Scientific Nectin 1 Monoclonal Antibody (R1.302)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody recognizes an extracellular epitope on CD111 (Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.

Target Information

The Nectin 1 gene encodes an adhesion protein involved in the organization of adherens and tight junctions in epithelial and endothelial cells. It is a calcium-independent cell-cell adhesion molecule belonging to the immunoglobulin superfamily, with 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region.
Nectin 1 acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus, mediating viral entry into epithelial and neuronal cells. Mutations in this gene are associated with cleft lip and palate/ectodermal dysplasia 1 syndrome and non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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