Thermo Fisher Scientific CD120a (TNF Receptor I) Monoclonal Antibody (H398)
CD120a(TNF Receptor I) 단클론 항체(H398)는 인간 TNFR1의 세포외 도메인을 인식하며 TNF-α 및 TNF-β의 생물학적 활성을 차단합니다. 다양한 면역분석(IHC, Flow, IP)에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-Dependent |
| Functional Assay (Functional) | Assay-Dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H398 |
| Immunogen | Recombinant full length human CD120a |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745559 |
Product Specific Information
This antibody recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor.
It blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
Functional Application: Blocking
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors.
It plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 is released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1, regulating its signal transduction.
Mutations in the extracellular domain are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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