Thermo Fisher Scientific IL-8 (CXCL8) Polyclonal Antibody
고양이 IL-8 단백질을 인식하는 Thermo Fisher의 폴리클로날 항체로, Western blot, ICC/IF, 중화실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 40%의 개 IL-8 교차반응성을 보입니다. 동결건조 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Neutralization (Neu) | 0.1–0.4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant feline CXCL8/IL-8 (Ala23–Ala101) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576462 |
Product Specific Information
- In direct ELISAs, approximately 40% cross-reactivity with recombinant canine IL-8 is observed.
- 15% cross-reactivity with recombinant porcine IL-8 and recombinant human IL-8 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72-amino-acid pro-inflammatory chemokine belonging to the CXC subfamily. It binds to receptors IL-8RA and IL-8RB and acts as a chemoattractant and angiogenic factor.
IL-8 expression is induced by inflammatory stimuli in macrophages and endothelial cells, where it is stored in Weibel-Palade bodies.
The protein contains the ELR-motif (Glu-Leu-Arg) and signals through CXCR1 and CXCR2 receptors.
Previous names include NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related CXC chemokines form a gene cluster on chromosome 4q.
It plays roles in tumor angiogenesis and growth, and in inflammatory diseases such as bronchiolitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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