Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC275)

Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC275)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and plays crucial roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with its regulation.

c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc induces apoptosis and contributes to neoplastic transformation. Antibodies against c-Myc epitopes recognize overexpressed Myc-tagged proteins fused to amino- or carboxy-termini of target proteins.

Amplification of the c-Myc gene is observed in various human tumors, including lung, breast, and colon carcinomas. N-Myc amplification is typical in neuroblastomas, while c-Myc translocation to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression occurs in tumors of multiple origins such as colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.