Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI7H6), TrueMAB
LPIN1 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot 및 IHC(Paraffin) 실험에 적합. Human 시료 반응성, carrier-free 형태로 재결합 및 결합 실험에 활용 가능. 지방 대사 및 인슐린 감수성 연구에 유용.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7H6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–274 of human LPIN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, an N-terminal (NLIP) domain, and a C-terminal (CLIP) domain.
LPIN1 (Lipin-1) plays a critical role in adipose tissue development and metabolism. It activates pathways involved in fatty acid oxidation and mitochondrial oxidative phosphorylation via PGC-1A and PPARA.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Excess LPIN1 enhances fat accumulation and insulin sensitivity, while deficiency may lead to insulin resistance and lipodystrophy characterized by fat loss, fatty liver, and hypertriglyceridemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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