Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI7H6), TrueMAB

Applications

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, an N-terminal (NLIP) domain, and a C-terminal (CLIP) domain.
LPIN1 (Lipin-1) plays a critical role in adipose tissue development and metabolism. It activates pathways involved in fatty acid oxidation and mitochondrial oxidative phosphorylation via PGC-1A and PPARA.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Excess LPIN1 enhances fat accumulation and insulin sensitivity, while deficiency may lead to insulin resistance and lipodystrophy characterized by fat loss, fatty liver, and hypertriglyceridemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.