Thermo Fisher Scientific ANGPT2 Monoclonal Antibody (OTI4A3), TrueMAB
인간 ANGPT2 단백질에 특이적인 마우스 단클론 항체로 Western blot에 적합합니다. 동결건조 형태이며 1 mg/mL 농도로 제공됩니다. PBS 버퍼(8% trehalose)로 안정화되어 있으며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–496 of human ANGPT2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation. ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2-induced angiogenesis depending on the environment.
ANG-1, ANG-2, Tie-2, and related ANG-3/ANG-4 interactions are essential for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of new blood vessels.
Mature human ANG-2 is a secreted protein with 480 amino acids, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, predominantly forming disulfide-linked dimers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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