Thermo Fisher Scientific IRF3 Recombinant Rabbit Monoclonal Antibody (SD2062)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses.
IRF3 regulates transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to interferon-stimulated response elements (ISRE) in their promoters. It acts as a potent activator of IFN-beta gene and functions in both early and late phases of IFNA/B gene induction.
In uninfected cells, IRF3 remains inactive in the cytoplasm. Upon viral infection or toll-like receptor signaling, it is phosphorylated by IKBKE and TBK1 kinases, leading to dimerization, nuclear localization, and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1). This complex activates transcription of type I IFN and ISG genes.
Mutations in IRF3 can result in acute infection-induced encephalopathy (herpes-specific type 7).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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