Thermo Fisher Scientific Cyclin E Recombinant Rabbit Monoclonal Antibody (SD20-24)
Cyclin E 단백질 검출용 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF에 적합합니다. 높은 특이성과 민감도, 로트 간 일관성을 제공합니다. HEK293 발현 시스템에서 생산되며, 장기 보관 시 -20°C에서 안정적입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD20-24 |
| Immunogen | Synthetic peptide within Human Cyclin E1 (aa 361–410) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809630 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Cyclin E belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance throughout the cell cycle. Cyclins regulate CDK kinases, with distinct expression and degradation patterns ensuring proper mitotic coordination.
Cyclin E forms a complex with CDK2, essential for the G1/S transition. It accumulates at the G1–S boundary and is degraded during S phase. Overexpression has been observed in many tumors, contributing to chromosomal instability and tumorigenesis. Cyclin E also interacts with NPAT, promoting histone gene expression and cell-cycle progression independently of pRB.
Two alternatively spliced transcript variants encode distinct isoforms, and two additional splice variants have been reported but not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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