Thermo Fisher Scientific RelB Recombinant Rabbit Monoclonal Antibody (SD07-39)
RelB 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 높은 특이성과 재현성을 제공하며, lot 간 일관성이 우수합니다. 단백질 A로 정제된 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD07-39 |
| Immunogen | Synthetic peptide within Human RelB aa 1–50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809631 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in these systems. Individual clones are screened to select the best candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The NFκB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNA-binding subunit is functionally related to c-Rel p75 and RelB p68. The p50 subunit is derived from a precursor designated p105, while p52 (previously p49) can act as an alternative NFκB subunit.
RelB does not bind strongly to NFκB sites alone, but RelB/p50 heterodimers bind with an affinity comparable to p50 NFκB homodimers. Unlike NFκB heterodimers, RelB/p50 heterodimers transactivate promoters containing κB binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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