Thermo Fisher Scientific Cyclophilin A Polyclonal Antibody
Cyclophilin A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC(파라핀) 실험에 적합하며, 인간·마우스·랫 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 고순도 제품으로 연구용으로만 사용 가능.
- 카탈로그번호
- PA529752
- 판매단위
- pk
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Thermo Fisher Scientific Cyclophilin A Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:500–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–165 of Human Cyclophilin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2547226 |
Product Specific Information
- Recommended positive controls: Raji WCE, Raji C+M, Raji NE, Molt-4, Raji, Mouse brain
- Predicted reactivity: Mouse (96%), Rat (96%), Cat (98%), Pig (99%), Rabbit (96%), Chicken (92%), Sheep (99%), Rhesus Monkey (100%), Bovine (94%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents, cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase implicated in T-cell activation. Immunophilins act as peptidyl prolyl cis-trans-isomerases (PPIase), accelerating folding of proline-containing proteins.
Within the cyclophilin family, CyPA (also termed CyP-18) is the most abundant and ubiquitous member, found in all vertebrate tissues and present in T-cells.
Safety Information
⚠ WARNING: This product contains mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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