Thermo Fisher Scientific Lactoferrin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: human milk
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Lactoferrin (LF) is an iron-binding glycoprotein consisting of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of binding one ferric ion (Fe³⁺). It is found in external fluids such as milk and mucosal secretions and is a key component of neutrophil secondary granules.
LF exhibits diverse biological activities including:

• Regulation of iron homeostasis
• Host defense against microbial infections
• Anti-inflammatory activity
• Regulation of cell growth and differentiation
• Protection against cancer development and metastasis

Lactoferrin acts as a first line of defense by binding Fe³⁺ and depriving pathogens of iron. It also shows bactericidal and proteolytic activity, capable of cleaving arginine-rich sequences in microbial proteins.
Three isoforms—LTF-α, LTF-β, and LTF-γ—have been identified, and receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.