Thermo Fisher Scientific Lactoferrin Polyclonal Antibody
Thermo Fisher Scientific의 Lactoferrin Polyclonal Antibody는 인간 Lactoferrin 단백질을 인식하는 토끼 다클론 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 사용되며 장기 보관 시 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 98–412 of Human Lactoferrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547218 |
Product Specific Information
- Recommended positive control: human milk
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Lactoferrin (LF) is an iron-binding glycoprotein consisting of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of binding one ferric ion (Fe³⁺). It is found in external fluids such as milk and mucosal secretions and is a key component of neutrophil secondary granules.
LF exhibits diverse biological activities including:
- Regulation of iron homeostasis
- Host defense against microbial infections
- Anti-inflammatory activity
- Regulation of cell growth and differentiation
- Protection against cancer development and metastasis
Lactoferrin acts as a first line of defense by binding Fe³⁺ and depriving pathogens of iron. It also shows bactericidal and proteolytic activity, capable of cleaving arginine-rich sequences in microbial proteins.
Three isoforms—LTF-α, LTF-β, and LTF-γ—have been identified, and receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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