Thermo Fisher Scientific Complement C4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunoprecipitation (IP)

1:50

-

Inhibition Assays (IA)

1:50

-

Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

The polyclonal antibody reacts with Rat C4 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Complement C4,uniProtId:P08649-1,ncbiNodeId:10114,antigenRange:1-1737,antigenLength:1737,antigenImageFileName:PA5-143803_Complement_C4_P08649-1_Rabbit.svg,antigenImageFileNamePDP:PA5-143803_Complement_C4_P08649-1_Rabbit_PDP.jpeg,sortOrder:4}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

100 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_3091723

Target Information

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.