Thermo Fisher Scientific Phospho-WAVE1 (Tyr125) Polyclonal Antibody
Phospho-WAVE1 (Tyr125) 특이적 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot과 면역세포염색(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 actin 재구성 연구에 유용한 연구용 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-WAVE (Tyr-125) peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-125 in human WAVE1. This sequence has high homology with similar regions in rat and mouse WAVE1, and has less than 50% homology to similar regions in the conserved site in WAVE2 (Tyr-124) and WAVE3 (Tyr-125). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2943022 |
Product Specific Information
This antibody was cross-adsorbed to phospho-WAVE (Tyr-150) and unphosphorylated WAVE (Tyr-125) peptides before affinity purification using phospho-WAVE (Tyr-125) peptide.
In western blots, the antibody detects an 80 kDa band corresponding to phosphorylated WAVE in human SYF cSrc transformed cells and mouse macrophages treated with pervanadate, but is not observed in control cells.
These bands can be specifically blocked with phospho-WAVE (Tyr-125) peptide (WX1775), but not phospho-WAVE (Tyr-150) peptide (WX1825).
Target Information
WASP (Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization.
The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (mammalian enabled protein), which accumulate at focal adhesions and regulate actin cytoskeleton.
WAVE proteins, related to the WASP family, mediate actin reorganization downstream of Rho family GTPases.
WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing actin filament clusters in response to Rac activation.
These proteins cooperate with the Arp2/3 complex to promote actin filament formation.
WAVE1 (also called SCAR) is primarily expressed in the brain, WAVE2 is widely expressed with high levels in leukocytes, and WAVE3 links receptor kinases to actin.
All family members bind actin through a C-terminal verprolin homology domain.
The WAVE multiprotein complex transduces signals that regulate cell shape, motility, and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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