Thermo Fisher Scientific OATP1 Polyclonal Antibody
OATP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. 고순도(>95%) 항원 친화 크로마토그래피 정제 제품. PBS/glycerol buffer에 보관되며, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 250–300 of human OATP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553610 |
Product Specific Information
- Detects endogenous OATP1 protein at approximately 76 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The organic anion transporting polypeptides (OATPs), including OATP-A (also known as OATP1, OATP1A2, SLC21A3) and OATP-C (OATP2, SLC21A6, LST1), mediate hepatic uptake of cardiac glycosides.
OATP-C expression is inducible by phenobarbital and pregnenolone-16α-carbonitrile, enhancing hepatic extraction of cardiac glycosides from plasma.
OATP-A is expressed in liver and kidney, facilitating sodium-independent uptake of anionic steroid conjugates such as dehydroepiandrosterone sulfate, estradiol-17-glucuronide, and prostaglandin.
OATP-C is exclusively expressed in the liver and localized to the basolateral hepatocyte membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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