Thermo Fisher Scientific Phospho-WASP (Tyr290) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

The Wiskott-Aldrich syndrome family of proteins share similar domain structure and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by multiple stimuli and interact with various proteins.
Studies show association with small GTPase Cdc42, regulating actin filament formation, and the Arp2/3 complex.
Wiskott-Aldrich syndrome is a rare X-linked recessive disease caused by mutations in the WAS gene, leading to immune dysregulation and microthrombocytopenia.
The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, showing signaling and cytoskeletal abnormalities in patients.
A transcript variant arising from alternative promoter usage with a different 5’ UTR sequence has been described, though its full-length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.