Thermo Fisher Scientific Phospho-Zap-70 (Tyr315) Polyclonal Antibody
Rabbit polyclonal antibody targeting phosphorylated ZAP-70 (Tyr315). Suitable for WB and IHC(P) applications. Recognizes human ZAP-70 involved in T-cell receptor signaling. Supplied as liquid, unconjugated form, 1 mg/mL concentration.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ZAP-70 around the phosphorylation site of Tyr315 (S-V-YP-E-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554951 |
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family. It is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP-70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains. Phosphorylation of Tyr315 (Vav binding site) and Tyr319 (Lck binding site) enhances ZAP-70 function in lymphocyte signaling, whereas phosphorylation of Tyr292 terminates activation and attenuates signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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