Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), PE

Applications

• Flow Cytometry (Flow): 5 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA5-36965)
• APC (MA5-36968)
• FITC (MA5-36967)
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened for optimal performance.
Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broad immunoreactivity due to the large rabbit immune repertoire

Target Information

EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression of EGFR has been associated with multiple cancers and serves as a therapeutic target for biological and small molecule inhibitors.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ERbB family, which also includes ERbB2, ERbB3, and ERbB4.
Ligand binding (e.g., EGF, TGF-α) induces receptor dimerization and autophosphorylation of tyrosine residues, triggering downstream signaling pathways.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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