Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), APC
Phospho-EGFR (Tyr1068) 인산화 부위를 특이적으로 인식하는 재조합 토끼 단일클론 항체입니다. APC 형광표지로 유세포분석(Flow Cytometry)에 적합하며, 높은 특이성과 재현성을 제공합니다. 인간 및 마우스 시료에 반응합니다.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EGFRY1068-E5 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745008 |
Additional Formats
- Unconjugated (MA5-36965)
- FITC (MA5-36967)
- PE (MA5-36966)
- Custom conjugation available upon request
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression of EGFR is associated with multiple cancer types and serves as a therapeutic target for biological and small molecule drugs.
EGFR is encoded on human chromosome 7 and belongs to the HER/ErbB family (ErbB2, ErbB3, ErbB4). Ligand binding (e.g., EGF, TGF-α) induces receptor dimerization and autophosphorylation at tyrosine residues, activating downstream signaling pathways.
Overexpression is observed in cancers of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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