Thermo Fisher Scientific HEXB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a tetramer of two β-A and two β-B chains and is found in lysosomes. Mutations in the HEXB gene cause Sandhoff disease (GM2-gangliosidosis type II), leading to deficient HEXB and HEXA enzyme activity and accumulation of GM2 ganglioside in the brain. This results in progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease, but typically more severe.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.