Thermo Fisher Scientific Phospho-IRF7 (Ser471, Ser472) Polyclonal Antibody
인간, 생쥐, 랫드의 IRF7 단백질 Ser471/472 인산화 부위를 특이적으로 인식하는 polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. PBS와 50% glycerol 용액에 보관되며 -20°C에서 안정적. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRF7 around the phosphorylation site of Ser471/472 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899228 |
Product Specific Information
This antibody detects endogenous levels of IRF7 only when phosphorylated at Ser471/472.
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors like IFN regulatory factor-3 (IRF3), which can stimulate transcription of IFN-α/β genes.
IRF7 plays a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It is a key component in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their functions are not yet clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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