Thermo Fisher Scientific Phospho-Aconitase 1 (Ser711) Polyclonal Antibody
Phospho-Aconitase 1 (Ser711) 항체로, 인간·마우스·랫트 시료에서 인산화된 IREB1 검출에 적합합니다. Western blot과 ICC/IF에 사용 가능하며, 액상 형태로 -20°C에 보관합니다. PBS와 50% 글리세롤 버퍼, 0.02% sodium azide를 포함합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IREB1 around the phosphorylation site of Ser711 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899226 |
Product Specific Information
This antibody detects endogenous levels of IREB1 only when phosphorylated at Ser711.
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs) and plays a central role in cellular iron homeostasis. It also exhibits aconitase activity and belongs to the aconitase enzyme family. IREs are stem-loop structures located in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA. Iron-induced binding to IRE represses ferritin translation and stabilizes transferrin receptor mRNA, thereby regulating iron metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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