Thermo Fisher Scientific Phospho-IRF7 (Ser437, Ser438) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of IRF-7 only when phosphorylated at Ser437/438.

Target Information

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions signal downstream molecules such as transcription factors including IFN regulatory factor-3 (IRF3), which can act to stimulate transcription of IFN-α/β genes.
IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
IRF7 plays a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.