Thermo Fisher Scientific CCR5 Recombinant Rabbit Monoclonal Antibody (ST6)
CCR5 단백질을 인식하는 재조합 토끼 단클론 항체로, 인간 및 붉은털원숭이 반응성 검증됨. WB, ICC, Flow 등 다양한 분석에 사용 가능. HIV 관련 연구 및 CCR5 기능 분석에 적합. 고순도 Protein A 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | 1:100 | |
| ELISA | Assay-dependent | |
| Functional Assay | Assay-dependent | |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rhesus monkey |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST6 |
| Immunogen | Isolated from a phage displayed antibody fragment library generated from a New Zealand White rabbit immunised with purified CCR5-N-GST protein. Four rounds of panning were completed against immobilised CCR5-N-MBP antigen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for the YTSE region of the N-terminal extracellular domain of human CCR5. It also binds to rhesus CCR5.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. CCR5 is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, mediating fusion and entry of human white blood cells. CCR5 is required for infection by HIV-1, HIV-2, and SIV.
Beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 interacts with the surface CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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