Thermo Fisher Scientific CCR5 Recombinant Mouse Monoclonal Antibody (T21/8)
CCR5 단백질을 표적으로 하는 Mouse IgG2a 형 재조합 단클론 항체로, WB, ICC/IF, Flow, ELISA, IP 등 다양한 어플리케이션에 적합합니다. 높은 결합 친화도를 가지며 HIV 연구 및 케모카인 수용체 분석에 활용됩니다.
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Thermo Fisher Scientific CCR5 Recombinant Mouse Monoclonal Antibody (T21/8)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- ELISA: Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | T21/8 |
| Immunogen | This antibody was raised by immunizing mice with intact RBL-CCR5 cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
T21/8 antibody binds with high affinity to a CCR5 N-terminal epitope.
CCR5 is a receptor for several inflammatory CC-chemokines including CCL3 (MIP-1α), CCL4 (MIP-1β), and RANTES.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
CCR5, CXCR4, CCR3, CCR2b, and CCR8 are members of the chemokine receptor family that act as HIV coreceptors.
CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry of human white blood cells.
CCR5 is required for infection by HIV-1, HIV-2, and SIV.
Beta-chemokines such as RANTES, MIP-α, and MIP-β are CCR5 ligands that prevent infection by M-tropic HIV-1.
CCR5 associates with CD4-gp120 complexes of HIV, leading to membrane fusion and viral entry.
Its amino-terminal domain and extracellular loops serve as HIV binding sites.
CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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